What Happens in Radiation Therapy Lawrence W. Margolis, MD, and T. Stanley Meyler, MD About half of all people with cancer need radiation therapy as part of their overall treatment plan at some point in their illness. It is often recommended as the primary treatment, but can also be used along with chemotherapy or surgery. When used with surgery, it might be given before, during or after the operation. When used with chemotherapy, it may be given before or after the program begins or at the same time as chemotherapy. There are two main goals in radiation therapy: • Cure the cancer. This usually requires a long and complex course of treatment. • Relieve symptoms (palliation). Treatment to achieve this goal is usually less complex and takes less time.